True North Clinical Research

Providing Hope to Present and Future Generations

True North Clinical Research is committed to the health and wellness of patients living in Nova Scotia.

Why Clinical Research?

Clinical trials are an essential part of the research and development of all pharmaceutical drugs. All medication, whether sold through prescription or over-the-counter, must undergo comprehensive testing to ensure they treat the condition or conditions they were designed and created to treat without significant risk to those taking them.

Each and every trial we conduct is done so under strict guidelines, which are monitored by Health Canada. Health Canada approves the use of investigational medications within clinical trials, before these medications are approved for use by the general public. A Principal Investigator – a medical doctor trained to conduct research trials in a safe, ethical and controlled manner – oversees each of our research trials.

In order to qualify for a trial, participants are screened and must meet a strict criteria. Those participants who qualify to enroll in a trial will be required to attend a variety of appointments and their progress will be carefully tracked. During these visits, participants will work with our clinical staff and investigators. These visits could potentially include questionnaires, blood collection, physical exams, and diagnostic tests.

It should be noted that each participant is fully educated as to what to expect prior to undergoing any trial-related assessments that may be required.

Importance and Benefits of Participation

 

  • Contribution to the future development of medications worldwide
  • Access to potential treatment options that is currently not available to the general public
  • Constant monitoring and care provided by highly trained professionals
  • On-going support provided by clinical research staff
True North Clinical Memory and Alzheimer Conditions
How do I learn more?
If you are interested in learning more about clinical trials, or wish to inquire about out current or future trials, click here to contact us and one of our highly trained staff will be in touch to provide more information.

Recruiting Clinical Trials

Currently Recruiting New Participants
Alzheimer’s Disease – Buena

True North Clinical Research is involved in a clinical trial with IntelGenX, researching an investigational medication vs placebo in those with mild-moderate Alzheimer’s disease. The investigational medication being studied is a repurposed drug that is already on the market (Montelukast) and the sponsor is looking at the potential of this drug to reduce neuroinflammation in an effort to slow down the progression of memory loss due to Alzheimer’s disease. Participants must already be taking an acetylcholinesterase inhibitor such as Aricept in order to qualify to participate in the trial. This trial is evaluating the relationship between the investigational medication and the cognitive abilities of participants over a 26 week period.

Alzheimer’s Disease – vTv

True North Clinical Research is involved in a clinical trial with vTv Therapeutics, researching an investigational medication vs placebo in those with mild Alzheimer’s disease and Type 2 diabetes not treated with insulin. The investigational medication being studied is designed to reduce inflammation in the brain and prevent the build up of beta-amyloid plaques that scientists believe cause Alzheimer’s Disease.  Participants are allowed to already be taking an acetylcholinesterase inhibitor such as Aricept and still participate in the trial. Participant’s that qualify will be enrolled in the study for approximately 11 months which includes 6 months of treatment (or placebo).

Osteoarthritis of the Knee – Antibe Therapeutics

True North Clinical Research is involved in a clinical trial with Antibe Therapeutics, researching an investigational medication vs placebo in those with Osteoarthritis of the knee. The investigational medication being studied is designed to reduce inflammation and pain without causing gastrointestinal upset, which is a side effect of other commonly used arthritis treatments such as Naproxen.  Participant’s that qualify will be enrolled in the study for up to46 days which includes 14 days of treatment (or placebo).

Ongoing Clinical Trials

Recruitment Closed

MissionAD

Together with Eisai Co., Ltd., True North Clinical Research is researching an investigational medication vs placebo in those with early Alzheimer’s disease. This trial is evaluating the relationship between daily oral administration of Elenbecestat (a BACE inhibitor) and the cognitive and functional abilities of trial participants. Elenbecestat is designed to prevent the accumulation of beta-amyloid plaque in the brain and the theory is that by doing so, they will slow down the progression of Alzheimer’s disease.

AZTherapies

True North Clinical Research is involved in a clinical trial with AZTherapies, researching investigational medications vs placebo in those with early evidence of Alzheimer’s disease. The investigational medications being studied are repurposed drugs that are already on the market (inhaled Cromolyn and Ibuprofen) and the sponsor is looking at the potential of these drugs, taken in combination, to prevent the formation of harmful plaques that are believed to cause Alzheimer’s and to reduce neuroinflammation in an effort to slow down the progression of memory loss due to Alzheimer’s disease. This trial is evaluating the relationship between the investigational medication and the cognitive abilities of participants over a 72 week(1 year and 6 months) period.

BI 1346.23

True North Clinical Research is involved in a clinical trial with Boehringer Ingelheim, researching an investigational medication vs placebo in those with mild-moderate Alzheimer’s disease. The investigational medication being studied is designed to increase memory abilities in those with cognitive impairment. Participants are allowed to already be taking an acetylcholinesterase inhibitor such as Aricept and still participate in the trial. This trial is evaluating the relationship between the investigational medication and the cognitive abilities of participants over a 12 week period.

Marguerite Road

With Hoffman-La Roche, True North Clinical Research is involved in a clinical trial researching gantenerumab in patients with mild Alzheimer’s disease. This trial is evaluating the relationship between monthly subcutaneous infusions of gantenerumab (a monoclonal antibody) and the cognitive and functional abilities of trial participants. Gantenerumab is designed to remove beta-amyloid plaque from the brain and the theory is that by doing so, they will slow down the progression of Alzheimer’s disease.

Scarlet Road

True North Clinical Research is involved in a clinical trial with Hoffman-La Roche, researching gantenerumab in patients with prodromal Alzheimer’s disease. This trial is evaluating the relationship between monthly subcutaneous infusions of gantenerumab (a monoclonal antibody) and the cognitive and functional abilities of trial participants. Gantenerumab is designed to remove beta-amyloid plaque from the brain and the theory is that by doing so, they will slow down the progression of Alzheimer’s disease.

Completed Clinical Trials

True North Clinical Research has proudly participated in many trials that have the potential to impact the lives of hundreds of thousands of people around the globe. Below is a list of some of our completed trails.